Sleep-Disordered Breathing Is an Independent Risk Factor of Aborted Sudden Cardiac Arrest in Patients With Coronary Artery Spasm

• Sakakibara Mamoru

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Yamada Shiro

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Kamiya Kiwamu

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Yokota Takashi

  Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen

• Oba Koji

  Translational Research and Clinical Trial Center, Hokkaido University Hospital

• Tsutsui Hiroyuki

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

抄録

Background: Sleep-disordered breathing (SDB) is often associated with sudden cardiac arrest (SCA) during sleep. Coronary artery spasm (CS) also occurs during sleep and is rarely associated with SCA, but the role of SDB in the risk of SCA is unknown in CS patients. This study evaluated the breathing patterns during sleep in CS patients with a prior history of aborted SCA. Methods and Results: This study enrolled 24 patients (age 61.6±11.0 years, male/female 19/5) with CS proven by an acetylcholine provocation test. They were divided into 2 groups: prior history of aborted SCA due to fatal arrhythmia (SCA group; n=9) and no such history (no-SCA group; n=15). Patients underwent overnight polysomnography with ambulatory electrocardiography. The overall prevalence of SDB (apnea hypopnea index ≥15) was 45.8% in this cohort. SDB was more frequent in the SCA group than in the no-SCA group (88.9% vs. 20.0% P=0.001) and identified as a pivotal risk factor of aborted SCA (odds ratio: 38.9, 95% CI: 2.80–1,498.2, P=0.01). Very-low-frequency was significantly correlated with the apnea hypopnea index in patients with SCA (P=0.01, r=0.78) during sleep. Conclusions: SDB is a significant risk factor for SCA in CS patients and autonomic instability during sleep might be involved in this association.  (Circ J 2012; 76: 2204–2210)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 76 (9), 2204-2210, 2012

  一般社団法人 日本循環器学会

キーワード

• Autonomic nervous function
• Coronary artery spasm
• Fatal arrhythmia
• Sleep-disordered breathing
• Sudden cardiac arrest

詳細情報

• CRID: 1390001205103443968
• NII論文ID: 10030696838
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-12-0210
• COI: 1:CAS:528:DC%2BC38XhtlOmsrvF
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 22664723
• Web Site: https://www.jstage.jst.go.jp/article/circj/76/9/76_CJ-12-0210/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013306617
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可