Quasispecies of dengue virus

• Kurosu Takeshi

  Department of Virology, Research Institute for Microbial Diseases, Osaka University

抄録

Pathogenic viruses have RNA genomes that cause acute and chronic infections. These viruses replicate with high mutation rates and exhibit significant genetic diversity, so-called viral quasispecies. Viral quasispecies play an important role in chronic infectious diseases, but little is known about their involvement in acute infectious diseases such as dengue virus (DENV) infection. DENV, the most important human arbovirus, is a causative agent of dengue fever (DF) and dengue hemorrhagic fever (DHF). Accumulating observations suggest that DENV exists as an extremely diverse virus population, but its biological significance is unclear. In other virus diseases, quasispecies affect the therapeutic strategies using drugs and vaccines. Here, I describe the quasispecies of DENV and discuss the possible role of quasispecies in the pathogenesis of and therapeutic strategy against DENV infection in comparison with other viruses such as Hepatitis C virus, human immunodeficiency virus type 1, and poliovirus.

収録刊行物

• Tropical Medicine and Health

  Tropical Medicine and Health 39 (4SUPPLEMENT), S29-S36, 2011

  日本熱帯医学会

キーワード

• Primary infection
• Secondary infection
• immune response
• antibody-dependent enhancement
• Neutralization
• Serotype

詳細情報

• CRID: 1390001205219244416
• NII論文ID: 10030727226
• NII書誌ID: AA11912846
• DOI: 10.2149/tmh.2011-s02
• ISSN: 13494147
• ISSN: 13488945
• Web Site: https://search.jamas.or.jp/link/ui/2012278237
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
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