Cloning, Monoclonal Antibody Production, and Bodily Distribution Pattern of a Bovine Lipocalin
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- JAPARIDZE Tamar
- Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine
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- SENDA Akitsugu
- Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine
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- NOZAKI Hirofumi
- Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology
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- YANAGIDA Mayumi
- Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
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- SUZUKI Takumi
- Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
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- GANZORIG Khuukhenbaatar
- State Central Veterinary Laboratory State Central Veterinary Laboratory
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- KUSHI Yasunori
- Department of Materials and Applied Chemistry, Nihon University Department of Materials and Applied Chemistry, Nihon University
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- KIDA Katsuya
- Field Center of Animal Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine Field Center of Animal Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine
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- URASHIMA Tadasu
- Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine
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- BRUCKMAIER Rupert M.
- Veterinary Physiology, Vetsuisse Faculty, University of Bern Veterinary Physiology, Vetsuisse Faculty, University of Bern
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- FUKUDA Kenji
- Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine Department of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine
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抄録
A bovine lipocalin, previously identified as a putative odorant-binding protein in bovine colostrum (bcOBP), was cloned and expressed, and its monoclonal antibody was established. bcOBP was constantly secreted into milk on day of parturition until at least 10 d postpartum at a concentration of 181±39 μg/L. Besides milk, bcOBP occurred in the nasal mucus, saliva, amniotic fluid, vaginal discharge, and blood plasma. Despite its low concentration, the distribution pattern and the finding that bcOBP harbored a characteristic sequence motif, CxxxC, which is conserved among insect and mammal pheromone binding proteins, suggest that bcOBP functions as a pheromone carrier. The presence of bcOBP in the plasma at varied concentrations depending on the lactation period does not exclude the possibility that bcOBP is secreted into milk from the blood. Cross-reactivity of the monoclonal antibody indicated presence of proteins homologous to bcOBP in the colostrum of farm animals of Cetartiodactyla.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 76 (4), 712-720, 2012
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206478578176
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- NII論文ID
- 10030751590
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC38rjt1Wjug%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 023592933
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- PubMed
- 22484937
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可