ε-Viniferin Is More Effective Than Its Monomer Resveratrol in Improving the Functions of Vascular Endothelial Cells and the Heart

• ZGHONDA Nahla

  Graduate School of Life and Environmental Sciences, Tsukuba University Graduate School of Life and Environmental Sciences, Tsukuba University

• YOSHIDA Shigeki

  Graduate School of Life and Environmental Sciences, Tsukuba University Graduate School of Life and Environmental Sciences, Tsukuba University

• EZAKI Shoji

  Graduate School of Life and Environmental Sciences, Tsukuba University Graduate School of Life and Environmental Sciences, Tsukuba University

• OTAKE Yoshie

  Graduate School of Life and Environmental Sciences, Tsukuba University Graduate School of Life and Environmental Sciences, Tsukuba University

• MURAKAMI Chie

  Graduate School of Life and Environmental Sciences, Tsukuba University Graduate School of Life and Environmental Sciences, Tsukuba University

• MLIKI Ahmed

  Laboratory of Molecular Physiology of Grapevine, CBBC Laboratory of Molecular Physiology of Grapevine, CBBC

• GHORBEL Abdelwahed

  Laboratory of Molecular Physiology of Grapevine, CBBC Laboratory of Molecular Physiology of Grapevine, CBBC

• MIYAZAKI Hitoshi

  Graduate School of Life and Environmental Sciences, Tsukuba University Graduate School of Life and Environmental Sciences, Tsukuba University

抄録

The present study compared the effects of resveratrol and its dimer ε-viniferin on vascular endothelial cells (VECs) functions, and on the blood pressure and cardiac mass of spontaneously hypertensive rats (SHRs). Treatment of VECs with these compounds enhanced cell proliferation via nitric oxide generation and protected the cells from oxidative stress by suppressing increases in intracellular oxygen species. ε-Viniferin was more potent than resveratrol in most of these effects. ε-Viniferin, but not resveratrol inhibited angiotensin-converting enzyme activity in vitro. Three weeks of ε-viniferin treatment (5 mg/kg) reduced the systolic blood pressure and improved the whole cardiac mass and left ventricle mass indexes in SHRs. In contrast, resveratrol administration (2.5 mg/kg) failed to lower the blood pressure and significantly improve these mass indexes. These data suggest that ε-viniferin as well as resveratrol may be involved in protecting the functions of VECs and the heart.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 76 (5), 954-960, 2012

  公益社団法人 日本農芸化学会

キーワード

• angiotensin-converting enzyme
• ε-viniferin
• resveratrol
• spontaneously hypertensive rat
• vascular endothelial cell

詳細情報

• CRID: 1390282681455006848
• NII論文ID: 10030752844
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.110975
• COI: 1:STN:280:DC%2BC38jltlOnsw%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 023681926
• PubMed: 22738966
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023681926
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110975
• Web Site: https://search.jamas.or.jp/link/ui/2013092412
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可