大唾液腺癌42例の臨床検討

DOI 被引用文献2件 参考文献28件

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  • A clinical analysis of 42 cases of major salivary gland carcinomas

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To perform a statistical analysis of both clinical and pathological factors of prognostic significance for course-specific survival, we retrospectively reviewed the files of 42 patients with primary major salivary gland carcinoma treated mainly by surgery at our institution from 1999 to 2008. The primary tumor was in the parotid gland in 31 and in the submandibular gland in the other 11. The 5-year cause-specific survival rate of all 42 patients was 74.5%, and those of the parotid gland and submandibular gland were 76.3% and 70.1%, respectively. Eleven patients had histologically low grade malignancy (7: mucoepidermoid carcinoma, 3: acinic cell carcinoma, 1: basal cell carcinoma), 7 patients had intermediate grade (6: adenoid cystic carcinoma, 1: sebaceous carcinoma), 24 patients had high grade (2: adenoid cystic carcinoma, 5: adenocarcinoma, 7: salivary duct carcinoma, 2: squamous cell carcinoma, 6: carcinoma ex pleomorphic adenoma, 1: myoepithelial carcinoma, 1: lymphoepithelial carcinoma). Univariate analyses indicated that clinical T-stage, presence of lymph node metastasis, pathological grade, margin condition, presence of facial nerve dysfunction, lymphovascular invasion, and stage of disease were prognostic factors for cause-specific survival.<br>Multivariate analysis confirmed that only lymphovascular invasion was a prognostic factor for cause-specific survival. Therefore, lymphovascular invasion is suggested to be the most significant prognostic factor for major salivary gland carcinomas in this study.

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  • 頭頸部外科

    頭頸部外科 21 (1), 97-102, 2011

    特定非営利活動法人 日本頭頸部外科学会

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