Anti-Obesity Effects of Germinated Brown Rice Extract through Down-Regulation of Lipogenic Genes in High Fat Diet-Induced Obese Mice

• HO Jin-Nyoung

  Department of Medical Nutrition, Kyung Hee University

• SON Mi-Eun

  Department of Food and Biotechnology, Korea University

• LIM Won-Chul

  Department of Food and Biotechnology, Korea University

• LIM Seung-Taik

  Department of Food Technology, Korea University

• CHO Hong-Yon

  Department of Food and Biotechnology, Korea University

抄録

Lipid accumulation using Oil Red O dye was measured in 3T3-L1 murine adipocytes to examine the anti-obesity effect of four types of germinated rice, including germinated brown rice (GBR), germinated waxy brown rice (GWBR), germinated black rice (GB-R), and germinated waxy black rice (GWB-R). GBR methanol extract exhibited the highest suppression of lipid accumulation in the 3T3-L1 cell line and also the anti-obesity effect of GBR on high fat induced-obese mice. The mice were divided into three groups and were administered: ND, a normal diet; HFD control, a high fat diet; and GBR, a high fat diet plus 0.15% GBR methanol extract for 7 weeks. GBR administration significantly decreased body weight gain and lipid accumulation in the liver and epididymal adipose tissue as compared to the HFD control group. In addition, serum triglycerides (TGs) and total cholesterol (TC) levels were significantly decreased by following GBR administration compared with those in the HFD control group, whereas the high-density lipoprotein (HDL) cholesterol level increased. Furthermore, the mRNA levels of adipogenic transcriptional factors, such as CCAAT enhancer binding protein (C/EBP)-α, sterol regulatory element-binding protein (SREBP)-1c, and peroxisome proliferator activated receptors (PPAR)-γ, and related genes (aP2, FAS), decreased significantly. Taken together, GBR administration suppressed body weight gain and lipid accumulation in the liver and epididymal adipocytes, and improved serum lipid profiles, in part, by controlling adipogenesis through a reduction in transcriptional factors. These results suggest that GBR is a potential agent against obesity.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 76 (6), 1068-1074, 2012

  公益社団法人 日本農芸化学会

キーワード

• germinated brown rice
• 3T3-L1
• high fat-induced obese mice
• anti-obesity

詳細情報

• CRID: 1390282681454725632
• NII論文ID: 10030817677
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.110666
• COI: 1:STN:280:DC%2BC38jps1Gitg%3D%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 023768053
• PubMed: 22790925
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023768053
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110666
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可