Usefulness of l-[methyl-11C]methionine positron emission tomography in the treatment of idiopathic hypertrophic cranial pachymeningitis—case report

• MIYAKE Keisuke

  Department of Neurological Surgery, Kagawa University Faculty of Medicine

• OKADA Masaki

  Department of Neurological Surgery, Kagawa University Faculty of Medicine

• HATAKEYAMA Tetsuhiro

  Department of Neurological Surgery, Kagawa University Faculty of Medicine

• OKAUCHI Masanobu

  Department of Neurological Surgery, Kagawa University Faculty of Medicine

• SHINDO Atsushi

  Department of Neurological Surgery, Kagawa University Faculty of Medicine

• KAWANISHI Masahiko

  Department of Neurological Surgery, Kagawa University Faculty of Medicine

• KAWAI Nobuyuki

  Department of Neurological Surgery, Kagawa University Faculty of Medicine

• TAMIYA Takashi

  Department of Neurological Surgery, Kagawa University Faculty of Medicine

書誌事項

タイトル別名

• Usefulness of L-[Methyl-¹¹C]Methionine Positron Emission Tomography in the Treatment of Idiopathic Hypertrophic Cranial Pachymeningitis
• —Case Report—

抄録

A 53-year-old man suffered from pulsating headache for 2 months. Magnetic resonance imaging with gadolinium revealed a linear or nodular mass along the left fronto-parietal convexity. Positron emission tomography (PET) with L-[methyl-¹¹C]methionine (¹¹C-MET) demonstrated increased uptake in the enhanced lesion. Biopsy, obtained by craniotomy, demonstrated granulation with lymphocyte and plasma cell infiltration, suggesting inflammatory changes, and a diagnosis of idiopathic hypertrophic cranial pachymeningitis (IHCP) was made. Steroid therapy resulted in improvement of the clinical symptoms and shrinkage of the enhanced lesion in a week. Follow-up ¹¹C-MET PET study, after 18 months of steroid therapy, demonstrated significantly decreased uptake in the lesion, so the steroid therapy was discontinued. Neither clinical nor radiological recurrence was observed one year after discontinuation of the steroid therapy. This case of IHCP with increased ¹¹C-MET uptake, which then decreased after steroid therapy suggests that ¹¹C-MET PET is a useful monitoring modality for therapeutic efficacy against IHCP, and can indicate the appropriate timing of therapy discontinuation.<br>

収録刊行物

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 52 (10), 765-769, 2012

  一般社団法人 日本脳神経外科学会

キーワード

• idiopathic hypertrophic cranial pachymeningitis
• L-[methyl-¹¹C]methionine positron emission tomography
• high-dose corticosteroid therapy
• headache
• immunoglobulin G4-related disease

詳細情報

• CRID: 1390282680033131392
• NII論文ID: 10030873556
• NII書誌ID: AN00358613
• DOI: 10.2176/nmc.52.765
• COI: 1:STN:280:DC%2BC3s%2FnvVKkug%3D%3D
• ISSN: 13498029
• ISSN: 04708105
• PubMed: 23095274
• Web Site: https://www.jstage.jst.go.jp/article/nmc/52/10/52_3047/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013357424
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可