Spontaneous Multiple Focal to Massive Hepatic Necrosis in Guinea Pigs.

• Maeda Hiroshi

  Shin Nippon Biomedical Laboratories Co., Ltd., 2438 Miyanoura, Yoshida-cho, Kagoshima 891-1394, Japan

• Kawaguchi Hiroaki

  The Deartment of Pathology I, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan

• Sato Kenichi

  Shin Nippon Biomedical Laboratories Co., Ltd., 2438 Miyanoura, Yoshida-cho, Kagoshima 891-1394, Japan

• Satake Shigeru

  Shin Nippon Biomedical Laboratories Co., Ltd., 2438 Miyanoura, Yoshida-cho, Kagoshima 891-1394, Japan

• Izumi Hiroyuki

  Shin Nippon Biomedical Laboratories Co., Ltd., 2438 Miyanoura, Yoshida-cho, Kagoshima 891-1394, Japan

• Miyajima Hiroaki

  Shin Nippon Biomedical Laboratories Co., Ltd., 2438 Miyanoura, Yoshida-cho, Kagoshima 891-1394, Japan

抄録

One hundred and eleven cases of multiple focal to massive hepatic necrosis were noted out of 202 guinea pigs, aged between 4 and 23 weeks, purchased from 3 different Japanese breeding colonies. Guinea pigs with hepatic lesions showed no abnormal clinical symptoms. The occurrence of lesions peaked at 5 weeks of age in males, and 10 weeks of age in females. Grossly, yellowish white lesions, up to 10 mm in diameter, were observed singly or scattered in the liver. Histopathologically, the commonest lesions consisted of coagulative necrosis or vacuolation of hepatocytes in the central area, and macrophage/lymphocyte infiltration and regeneration of bile ducts around the peripheral area. The cytoplasm of the necrotic hepatocytes and macrophages often contained mineral granules, which were thought to be the dystrophic mineralization and associated with a concomitant occurrence of chronic nephropathy. The other organs examined revealed no significant lesions related to the hepatic lesions. Light and electron microscopic examinations failed to uncover causal organisms; an experimental infection by inoculation of extract from the guinea pig hepatic lesions to immuno-suppressed mice failed to cause hepatic lesions.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 13 (4), 207-212, 2000

  日本毒性病理学会

キーワード

• Guinea Pigs
• Necrosis
• Calcinosis
• Liver

詳細情報

• CRID: 1390001204414671488
• NII論文ID: 10030906441
• NII書誌ID: AA12022786
• DOI: 10.1293/tox.13.207
• ISSN: 1881915X
• ISSN: 09149198
• Web Site: http://www.jstage.jst.go.jp/article/tox/13/4/13_4_207/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2001108471
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可