Histopathological and Immunohistochemical Studies in Female Beagle Dogs during Four Years Treatment with Implantation of Chlormadinone Acetate(CMA).
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- Murakoshi Masanori
- Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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- Ikeda Rie
- Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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- Tagawa Masashi
- Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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- Iwasaka Toshio
- Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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- Nakayama Takaharu
- Safety Research Department, Teikoku Hormone Mfg. Co., Ltd.
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抄録
The histopathological changes related to chlormadinone acetate (CMA) implantation were examined using female beagle dogs given 10 mg/kg for four years. Estrus was completely inhibited in the CMA-implanted animals. In contrast, all control animals showed sign of estrus during the experiment, with periods of anestrus of normal duration. Histopathlogically, uterine sections from the CMA-implanted animals showed cystic glandular hyperplasia, but no histologic evidence of endometritis, myometritis, and pyometra was found. In the ovaries of the CMA-implanted animals, developing ovarian follicles were observed but no mature follicles were noted in addition to an absence of corpus luteum. No remarkable changes were observed in liver, adrenal, mammary gland, gallbladder, and implanted site. Furthermore, the intensity of staining and number of adrenocorticotropic hormone (ACTH)- and luteininzing hormone (LH)-positive cells in the pituitary sections of CMA-implanted animals were not different from the control animals. It was concluded, therefore, that subcutaneous implantation of CMA (10 mg/kg) is nearly equivalent to the minimal ovulation-suppressing dose.
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 14 (1), 9-12, 2001
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679391475840
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- NII論文ID
- 10030906731
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- NII書誌ID
- AA12022786
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- DOI
- 10.1293/tox.14.9
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- COI
- 1:CAS:528:DC%2BD3MXjtVyhtbs%3D
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- ISSN
- 1881915X
- 09149198
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可