神経麻酔を究める:序論

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  • Introduction to the Symposium on Forefront Neuroanesthesia

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  It is well known that the central nervous system (CNS) is especially vulnerable to hypoxia and ischemia. Therefore, it is of great importance to deliver sufficient oxygen and glucose, which is the only source of energy metabolism in the CNS, by cerebral blood flow (CBF). As an introduction to the symposium on forefront neuroanesthesia, the following elementary items are described: CBF, cerebral metabolic rate of oxygen (CMRO2), the effects of anesthetics on CBF and CMRO2, intracranial pressure, CNS monitoring, i.e., transcranial Doppler ultrasonography, cerebral tissue oxygen saturation, evoked potential (auditory, visual, somatosensory, and motor), mechanisms of neuronal cell death by ischemia and reperfusion, and neuroprotective strategies focusing on xenon gas, hydrogen molecules, and protein transduction.

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