Circulating Factor VII Activating Protease (FSAP) Is Associated With Clinical Outcome in Acute Coronary Syndrome

DOI Web Site PubMed 参考文献37件
  • Parahuleva Mariana S.
    Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg
  • Hölschermann Hans
    Krankenhaus Bad Homburg, Innere Medizin I Kardiologie Krankenhaus Bad Homburg, Innere Medizin I Kardiologie
  • Zandt Daniel
    Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg
  • Pons-Kühnemann Jörn
    Medical Statistics, Justus-Liebig-University Medical Statistics, Justus-Liebig-University
  • Parviz Behnoush
    Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg
  • Weiskirchen Ralf
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH Institute of Clinical Chemistry and Pathobiochemistry, RWTH
  • Staubitz Anne
    Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg
  • Tillmanns Harald
    Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg
  • Erdogan Ali
    Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg
  • Kanse Sandip M.
    Institute for Biochemistry, Justus-Liebig-University Institute of Basic Medical Science, University of Oslo Institute for Biochemistry, Justus-Liebig-University Institute of Basic Medical Science, University of Oslo

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Background: Factor VII activating protease (FSAP) is a circulating serine protease strongly expressed in unstable plaques and may serve as a marker of plaque destabilization. The aim of this study was to examine the relation between plasma concentrations of FSAP and clinical instability and outcome in coronary artery disease (CAD). Methods and Results: Circulating FSAP concentration and activity, as well as FSAP mRNA expression in monocytes, were measured in 231 sequential patients who underwent coronary angiography because of stable angina pectoris (n=50), unstable angina pectoris (n=43), or acute myocardial infarction (n=87). FSAP activity, but not FSAP antigen concentration, was elevated in patients with CAD compared with a control group. Elevated FSAP activity (≥1.035 plasma equivalent units [PEU]/ml) indicated a significantly increased risk of death or non-fatal myocardial infarction during 1 year of follow-up as compared with patients with low activity of FSAP (odds ratio 1.895 [95% confidence interval 1.093–3.283]; P=0.023). Furthermore, there were no significant changes in the FSAP expression in monocytes from CAD and control subjects in the basal state but there were differences after stimulation with proinflammatory factors. Conclusions: Plasma FSAP activity was significantly increased in patients with acute coronary syndrome and may be involved in the pathogenesis of these conditions. High levels of FSAP activity were predictive of adverse events during follow-up, suggesting its potential role in risk stratification and clinical management of CAD patients.  (Circ J 2012; 76: 2653–2661)<br>

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  • Circulation Journal

    Circulation Journal 76 (11), 2653-2661, 2012

    一般社団法人 日本循環器学会

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