Fatty liver as a consequence and cause of insulin resistance: Lessons from type 2 diabetic liver
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- Takamura Toshinari
- Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan
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- Misu Hirofumi
- Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan
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- Ota Tsuguhito
- Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan
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- Kaneko Shuichi
- Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8641, Japan
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抄録
Obesity is less common in the Asian population, but Asian people may be susceptible to obesity-associated metabolic dysregulation. Accumulating evidence suggests that insulin resistance is closely associated with ectopic fat accumulation in the liver. Whether this correlation is due to a causal relationship between the conditions has long been the subject of debate. Insulin resistance and type 2 diabetes affects liver pathology, typically leading to nonalcoholic fatty liver disease (NAFLD) by dynamically altering the hepatic genes involved in glucose and lipid metabolism. Conversely, how overnutrition induces hepatic insulin resistance has been studied intensively, and has been shown to involve excessive energy flux into mitochondria, toxic lipids, reactive oxygen species, and hepatokines. In this review, we focus on NAFLD both as a consequence and as a cause of insulin resistance through lessons learned from the liver of patients with type 2 diabetes.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 59 (9), 745-763, 2012
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390001206299946624
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- NII論文ID
- 10031123118
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- NII書誌ID
- AA10901436
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- COI
- 1:STN:280:DC%2BC38fotVyksg%3D%3D
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- ISSN
- 13484540
- 09188959
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- PubMed
- 22893453
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可