Effect of Carnosine on Prooxidant^|^ndash;Antioxidant Balance in Several Tissues of Rats Exposed to Chronic Cold Plus Immobilization Stress
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- Kalaz Esra Betül
- Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Turkey
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- Evran Betül
- Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Turkey
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- Develi-Is Seval
- Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Turkey
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- Vural Pervin
- Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Turkey
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- Dogru-Abbasoglu Semra
- Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Turkey
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- Uysal Müjdat
- Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Turkey
書誌事項
- タイトル別名
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- Effect of Carnosine on Prooxidant–Antioxidant Balance in Several Tissues of Rats Exposed to Chronic Cold Plus Immobilization Stress
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In this study, we investigated the effect of L-carnosine (CAR) on prooxidant–antioxidant balance in several tissues of rats exposed to chronic stress. Both cold and immobilization stresses were applied to rats at the same time. In the stress group, rats were placed in restraint cages and kept in a cold room (+4°C) for 1 h for 21 days (5 days a week). Rats were injected with CAR (250 mg/kg, i.p.) at 30 min before stress application. Malondialdehyde, diene conjugate, protein carbonyl and nitrotyrosine levels, nonenzymatic (glutathione, vitamin E, and vitamin C), and enzymatic (catalase, superoxide dismutase and glutathione peroxidase) antioxidants were determined in the liver, heart, and brain tissues. Chronic cold plus immobilization stress was observed to affect especially the prooxidant–antioxidant status in the brain tissue of rats. This is the first report showing the beneficial effects of CAR on oxidative stress in the brain in rats exposed to stress.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 120 (2), 98-104, 2012
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282680155733504
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- NII論文ID
- 10031123551
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- NII書誌ID
- AA11806667
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- COI
- 1:CAS:528:DC%2BC38Xhs1SrtLfE
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 024025591
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- PubMed
- 23079503
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可