超音波造影剤ペルフルブタンガイドによる肝腫瘍に対するラジオ波焼灼療法の使用実態下における安全性ならびに有効性の検討

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  • The safety and the efficacy of radiofrequency ablation (RFA) guided by contrast-enhanced sonography with Perflubutane microbubbles for hepatic lesion in clinical practice
  • チョウオンパゾウエイザイ ペルフルブタンガイド ニ ヨル カン シュヨウ ニ タイスル ラジオハ ショウシャク リョウホウ ノ シヨウ ジッタイ カ ニ オケル アンゼンセイ ナラビニ ユウコウセイ ノ ケントウ

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To investigate the safety and the efficacy of RFA guided by contrast-enhanced ultrasound (CEUS) with perflubutane, we conducted a post-marketing surveillance on the subjects undergoing RFA on hepatic lesions with (SZ group) or without (C group) CEUS guide. We collected CRFs from 328 subjects as SZ group and 340 subjects as C group, and adverse events (AE) were reported 67.1%, 69.3% respectively. Nausea and vomiting were reported as adverse reactions from a subject in SZ group. There were no difference between two groups on the incidence and variety of AEs. Overall efficacy as RFA guide was 90.9%, visual improvement of lesions was 75.0%. Moreover, RFA success rate in the lesions of which visual confirmation of lesion in B mode were insufficient was significantly higher in SZ group. Perflubutane could be used as CEUS guide for RFA safely, and it was demonstrated that visual improvement by CEUS improves RFA success rate.<br>

収録刊行物

  • 肝臓

    肝臓 53 (11), 721-733, 2012

    一般社団法人　日本肝臓学会

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