Executive Dysfunction in Patients With Cerebral Hypoperfusion After Cerebral Angiostenosis/Occlusion

• ZHAO Jian-Hua

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• TIAN Xiao-Jun

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• LIU Yan-Xia

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• YUAN Bin

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• ZHAI Kai-Hua

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• WANG Chao-Wei

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• YUE Jun-Yan

  Department of Radiology, the First Affiliated Hospital of Xinxiang Medical University

• ZHANG Li-Jun

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• LI Qing

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• YAN Hai-Qing

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• LI Gui-Min

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

• JI Si-Bei

  Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University

抄録

Impairment of executive functions (EFs) was investigated in patients with cerebral hypoperfusion after cerebral angiostenosis/occlusion. Several EFs were measured in patients with cerebral angiostenosis/occlusion and healthy subjects. The vascular conditions, regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), mean transit time (MTT), time to peak (TTP), and delay time were assessed. The scores of the vascular stenosis/occlusion group were significantly lower than those of the control group. rCBV and rCBF were negatively correlated with the error response times in the Stroop test, and the persistent error responses in the Wisconsin Card Sorting Test (WCST) were positively correlated with the Montreal Cognitive Assessment (MoCA) scores. TTP was positively correlated with the reaction and error reaction times, and the persistent error response in WCST was negatively correlated with the times of sorting in WCST and MoCA scores. MTT was positively correlated with the persistent error response in WCST. In the Stroop test, delay time was positively correlated with response time, and negatively correlated with error response times, and the persistent error response in WCST and MoCA scores. Patients with cerebral hypoperfusion after cerebral angiostenosis/occlusion had executive dysfunctions in working memory, sustained attention, response inhibition, cognitive flexibility, thought organization, planning, and implementation. Moreover, their executive dysfunctions were related with the decline in rCBF and rCBV. The prolonged TTP, MTT, and delay time suggested a slow blood flow and the poor compensation of collateral circulation, resulting in impairment of the EFs.<br>

収録刊行物

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 53 (3), 141-147, 2013

  一般社団法人 日本脳神経外科学会

キーワード

• cerebral hypoperfusion
• cerebrovascular stenosis
• cerebrovascular occlusion
• executive function
• computed tomography perfusion imaging

詳細情報

• CRID: 1390001205056752512
• NII論文ID: 10031138792
• NII書誌ID: AN00358613
• DOI: 10.2176/nmc.53.141
• COI: 1:STN:280:DC%2BC3svpt1OjsA%3D%3D
• ISSN: 13498029
• ISSN: 04708105
• PubMed: 23524496
• Web Site: https://www.jstage.jst.go.jp/article/nmc/53/3/53_2012-0086/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2014180633
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可