Identification of High-Risk Brugada Syndrome Patients by Combined Analysis of Late Potential and T-Wave Amplitude Variability on Ambulatory Electrocardiograms
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- Yoshioka Koichiro
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Amino Mari
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Zareba Wojciech
- Heart Research Follow-up Program, Cardiology, University of Rochester Medical Center
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- Shima Makiyoshi
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Matsuzaki Atsushi
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Fujii Toshiharu
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Kanda Shigetaka
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Deguchi Yoshiaki
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Kobayashi Yoshinori
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Ikari Yuji
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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- Kodama Itsuo
- Nagoya University
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- Tanabe Teruhisa
- Department of Cardiovascular Medicine, Tokai University School of Medicine
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Background: Risk stratification is important in the management of Brugada syndrome (BrS). Late potentials (LPs) and T-wave amplitude variability (TAV) in high-resolution ambulatory electrocardiography (ECG) were retrospectively investigated. Methods and Results: One hundred and twenty-seven patients diagnosed with BrS on 12-lead ECG were classified into 3 groups: documented ventricular fibrillation (VF)/asystole (n=19), episodes of syncope alone (n=30), and asymptomatic (n=78). Healthy volunteers were enrolled as controls (n=25). In the BrS patients, LPs showed appreciable circadian periodicity; filtered QRS duration (fQRS) and duration of the terminal low-amplitude signal <40μV (LAS40) increased, whereas root mean square voltage of the terminal 40ms of the fQRS (RMS40) decreased at night compared with the day. TAV did not have such a circadian periodicity. LP-positive incidence (night-time) and peak TAV were as follows: VF/asystole>syncope/asymptomatic>control (P<0.001). VF/asystole was discriminated from control at a ratio of 81–84% by night-time LPs (fQRS >116ms, LAS40 >35ms, RMS40 <25μV) or peak TAV (>54μV); VF/asystole was discriminated from syncope/asymptomatic at a ratio of 60–69%, by night-time LPs (fQRS >122ms, LAS40 >42ms, RMS40 <18μV) or peak TAV (>58μV). Combined analysis of LPs and peak TAV increased the discriminant ratio up to 93% and 77%, respectively. Conclusions: Analysis of both LPs and TAV (taking circadian periodicity into account) is useful in identification of high-risk BrS patients. (Circ J 2013; 77: 610–618)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 77 (3), 610-618, 2013
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205105628032
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- NII論文ID
- 10031138948
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BC3svhtlKrug%3D%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 23439592
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可