Molecular Approaches and Modern Clinical Strategies for the Management of Helicobacter pylori Infection in Japan

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  • Suzuki Hidekazu
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
  • Nishizawa Toshihiro
    Division of Gastroenterology, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan
  • Tsugawa Hitoshi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
  • Hibi Toshifumi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan

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  • Molecular Approaches and Modern Clinical Strategies for the Management of <b><i>Helicobacter pylori</i></b> Infection in Japan

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Thirty years have passed since Warren and Marshall’s discovery of Helicobacter pylori (H.pylori). Since then, not only peptic ulcer diseases and chronic gastritis but also non-cardia gastric cancers have been recognized as diseases originating from H. pylori infection. Several combination therapies consisting of multiple antibiotics have been developed as first- or second-line regimens to eradicate H. pylori infection. Our extensive experience in the field of anti-H. pylori medicine suggests that clinicians should consider a possible role for unidentified, invisible pathogens to elucidate the pathogenesis and improve the treatment of refractory diseases of unknown etiology.

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