Multiple Pharmacological Actions of Centrally Acting Antitussives : Do They Target G Protein-Coupled Inwardly Rectifying K⁺ (GIRK) Channels?

DOI Web Site PubMed 被引用文献2件 参考文献53件
  • Takahama Kazuo
    Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan

書誌事項

タイトル別名
  • Multiple Pharmacological Actions of Centrally Acting Antitussives — Do They Target G Protein-Coupled Inwardly Rectifying K<SUP>+</SUP> (GIRK) Channels?
  • Multiple Pharmacological Actions of Centrally Acting Antitussives ^|^mdash; Do They Target G Protein-Coupled Inwardly Rectifying K+ (GIRK) Channels?

この論文をさがす

抄録

Antitussive drugs have been used for decades and their modes of action are well elucidated. However, recent studies on the mechanism of their antitussive action seem to be opening a new way for discovery or development of novel drugs for intractable brain diseases including psychiatric disorders. Antitussives inhibit the currents caused by activation of G protein-coupled inwardly rectifying K+ (GIRK) channels in neurons. In our own studies carried out so far, we found that antitussives possessing an inhibitory action on GIRK channels, similar to the effects of an enriched environment, ameliorate symptoms of intractable brain diseases in various animal models. In this review, the multiple pharmacological actions of the antitussives are described, and their mechanisms are discussed addressing GIRK channels as a possible molecular target.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (53)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ