Design and Synthesis of Novel Piperazine Derivatives with High Antibacterial Activity

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  • Maolan Zhang
    Research Center of Bioinspired Material Science and Engineering, College of Bioengineering, Chongqing University
  • Yuanliang Wang
    Research Center of Bioinspired Material Science and Engineering, College of Bioengineering, Chongqing University
  • Jiaoxia Sun
    Research Center of Bioinspired Material Science and Engineering, College of Bioengineering, Chongqing University
  • Jinchuan Wu
    Research Center of Bioinspired Material Science and Engineering, College of Bioengineering, Chongqing University
  • Weiwei Yan
    Research Center of Bioinspired Material Science and Engineering, College of Bioengineering, Chongqing University
  • Yuxi Zheng
    Research Center of Bioinspired Material Science and Engineering, College of Bioengineering, Chongqing University

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<jats:title>Abstract</jats:title> <jats:p>A novel antibacterial piperazine derivative (PE-B) has been prepared via the nucleophilic substitution reaction of poly(ethylenediaminetetraacetic dianhydride-co-piperazine) (PE) with n-butyl bromide. PE was synthesized by a condensation polymerization reaction of ethylenediaminetetraacetic dianhydride (EDTAD) and piperazine (PA). The thermoresponsive test results showed that the PE was thermoresponsive; however, when it was quaternized by n-butyl bromide, this performance disappeared. The antibacterial test results showed that both the PE and PE-B exhibited potent inhibitory activity on S. aureus and E. coli. Specifically, PE had better antibacterial ability against S. aureus, but PE-B showed similar antibacterial activity against S. aureus and E. coli.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 42 (3), 227-228, 2013-02-16

    Oxford University Press (OUP)

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