Dietary L-carnitine Improves Pulmonary Hypertensive Response in Broiler Chickens Subjected to Hypobaric Hypoxia
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- Yousefi Azam
- Department of Animal Science, Shahrekord University, Iran
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- Khajali Fariborz
- Department of Animal Science, Shahrekord University, Iran
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- Hassanpour Hossein
- Department of Basic Science, Shahrekord University, Iran
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- Khajali Zahra
- Shaheed Rajaei Cardiovascular, Medical and Research Center, Iran
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Abstract
The present study was conducted to examine the effects of L-carnitine on pulmonary hypertensive response in broiler chickens reared at high altitude and exposed to hypobaric hypoxia. A total of 192 day-old male broilers (Cobb 500) were randomly assigned to 4 treatments and 4 replicates of 12 chicks. A basal diet composed of mainly corn and soybean meal was formulated and served as a control. Three additional treatments were made by supplementing graded levels of L-carnitine (50, 100, and 150 mg/kg). Chicks received dietary treatments at free access from 1 to 42 days of age. Results indicated that feeding L-carnitine at 100 mg/kg caused a significant increase in plasma nitric oxide (NO) with concomitant decrease in plasma malonedialdehyde (MDA). The Lead II electrocardiogram indicated reductions of S wave amplitude for all three doses of L-carnitine relative to the control and the difference between the birds that received L-carnitine at 50 mg/kg and the control was significant (P<0.05). The right ventricular weight ratio (RV/TV) tended to decline when L-carnitine supplemented to diets. In conclusion, L-carnitine reduced ascites mortality in broiler chickens by increased NO production, reduced MDA concentration, and reduced right ventricular hypertrophy.
Journal
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- The Journal of Poultry Science
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The Journal of Poultry Science 50 (2), 143-149, 2013
Japan Poultry Science Association
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Details 詳細情報について
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- CRID
- 1390001205208583424
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- NII Article ID
- 10031167871
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- NII Book ID
- AA11564513
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- COI
- 1:CAS:528:DC%2BC3sXos1ymsrk%3D
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- ISSN
- 13490486
- 13467395
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- NDL BIB ID
- 024434419
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed