C型慢性肝炎に対するインターフェロン治療による甲状腺機能障害と抗甲状腺自己抗体に関する検討

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  • 森下 祐子
    Department of Gastroenterology and Hepatology, Kumamoto Shinto General Hospital
  • 宮瀬 志保
    Department of Gastroenterology and Hepatology, Kumamoto Shinto General Hospital
  • 原岡 克樹
    Department of Gastroenterology and Hepatology, Kumamoto Shinto General Hospital
  • 大内田 義博
    Department of Gastroenterology and Hepatology, Kumamoto Shinto General Hospital
  • 藤山 重俊
    Department of Gastroenterology and Hepatology, Kumamoto Shinto General Hospital
  • 佐々木 裕
    Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences Kumamoto University

書誌事項

タイトル別名
  • Thyroid dysfunction during interferon therapy for chronic hepatitis C and its relationship to de novo antithyroid antibodies
  • Cガタ マンセイ カンエン ニ タイスル インターフェロン チリョウ ニ ヨル コウジョウセン キノウ ショウガイ ト コウコウジョウセン ジコ コウタイ ニ カンスル ケントウ

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抄録

We examined thyroid function in 358 patients with chronic hepatitis C undergoing interferon (IFN) therapy. Prevalence of antithyroglobulin (TgAb) and antiperoxidase (TPOAb) antibodies before therapy was 10.8% and 9.4%, respectively. Of the 358 patients, 15 (4.2%) developed a thyroid disorder 1-19 months after IFN therapy had commenced. Of these 15 patients, 13 exhibited hypothyroidism and were TgAb- or TPOAb-positive. The remaining 2 patients exhibited signs of hyperthyroidism and neither antibody was detected. High titers of TgAb and TPOAb were seen in patients with thyroid dysfunction compared with subclinical patients. All patients completed IFN therapy. Our findings show that high TgAb and TPOAb titers were predictive factors of thyroid dysfunction during IFN therapy.<br>

収録刊行物

  • 肝臓

    肝臓 54 (4), 298-300, 2013

    一般社団法人　日本肝臓学会

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