Myofibroblasts: Biochemical and Proteomic Approaches to Fibrosis
-
- Honda Eiko
- Life Science Research Institute, Kinki University
-
- Park Ah-Mee
- Department of Biochemistry, Kinki University Faculty of Medicine
-
- Yoshida Koji
- Department of Biochemistry, Kinki University Faculty of Medicine
-
- Tabuchi Masaki
- Department of Biochemistry, Kinki University Faculty of Medicine
-
- Munakata Hiroshi
- Department of Biochemistry, Kinki University Faculty of Medicine
この論文をさがす
抄録
Fibrosis is a state, in which excess amounts of extracellular matrix are deposited in the tissue. Fibrosis can occur in various organs, including the liver, lung, kidney and heart. The progression of fibrosis involves interstitial hypercellularity, accumulation of extracellular matrix, and atrophy of epithelial structures, resulting in a loss of normal function. Myofibroblasts play a crucial role in the development and progress of fibrosis. When stimulated, myofibroblasts actively synthesize connective tissue components and cause organ fibrosis. As a result, the process and the mechanism of myofibroblast activation represent a target for antifibrotic treatment. As yet, however, an effective treatment has not been developed, and new treatment modalities are expected. Because activation of myofibroblasts is a key event during fibrosis development, there is great interest in identifying and characterizing proteins whose expression is changed after this activation. In this review, fibrosis is outlined and the role of myofibroblasts in this disorder is described. Furthermore, the search for candidate proteins to target for treatment and the prospects of antifibrotic therapy are discussed.
収録刊行物
-
- The Tohoku Journal of Experimental Medicine
-
The Tohoku Journal of Experimental Medicine 230 (2), 67-73, 2013
東北ジャーナル刊行会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679221817472
-
- NII論文ID
- 10031182993
-
- NII書誌ID
- AA00863920
-
- COI
- 1:CAS:528:DC%2BC3sXht1entbjO
-
- ISSN
- 13493329
- 00408727
-
- PubMed
- 23774326
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可