立体選択的グリコシル化から迅速オリゴ糖合成まで

• Yasomanee Jagodige P.

  Department of Chemistry and Biochemistry, University of Missouri—St. Louis, One University Boulevard

• Demchenko Alexei V.

  Department of Chemistry and Biochemistry, University of Missouri—St. Louis, One University Boulevard

書誌事項

タイトル別名

• From Stereocontrolled Glycosylation to Expeditious Oligosaccharide Synthesis

抄録

This article provides an overview of chemical methods, strategies and applications that have been introduced by our group during the past decade. The major discussion point is the development of new methods for chemical glycosylation. The methods overviewed here include: new leaving and protecting groups, metal-coordination assisted synthesis, picolinyl approach to stereoselective glycosylation, etc. Also discussed is the invention of strategies for efficient oligosaccharide assembly. Innovative tools for oligosaccharide synthesis including the temporary deactivation concept, the inverse armed-disarmed strategy, thioimidate-only orthogonal and active–atent activation, and O-2/O-5 cooperative effect are discussed in light of recent results. Our recent attempts to develop new automated technologies, i.e. Surface-Tethered Iterative Carbohydrate Synthesis (STICS) and HPLC-assisted oligosaccharide synthesis are also introduced.

収録刊行物

• Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ

  Ｔｒｅｎｄｓ　ｉｎ　Ｇｌｙｃｏｓｃｉｅｎｃｅ　ａｎｄ　Ｇｌｙｃｏｔｅｃｈｎｏｌｏｇｙ 25 (141), 13-42, 2013

  FCCA(Forum: Carbohydrates Coming of Age)

キーワード

• glycosyl donors
• carbohydrates
• glycosylation
• thioimidates
• stereoselective synthesis

詳細情報

• CRID: 1390282679345939456
• NII論文ID: 10031190617
• NII書誌ID: AA10995236
• DOI: 10.4052/tigg.25.13
• COI: 1:CAS:528:DC%2BC3sXhsFansbvN
• ISSN: 18832113
• ISSN: 09157352
• NDL書誌ID: 024812666
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024812666
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可