Organophosphate Urinary Metabolite Levels during Pregnancy, Delivery and Postpartum in Women Living in Agricultural Areas in Thailand
-
- Kongtip Pornpimol
- Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University
-
- Nankongnab Noppanun
- Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University
-
- Woskie Susan
- Department of Work Environment, University of Massachusetts Lowell
-
- Phamonphon Akkarat
- Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University
-
- Tharnpoophasiam Prapin
- Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University
-
- Wilaiwan Kitsiluck
- Paholpolpayuhasena Hospital
-
- Srasom Punnee
- Amnatcharoen Hospital
この論文をさがす
抄録
Objective: Prenatal exposure to organophosphate pesticides can lead to developmental neurotoxicity. A longitudinal birth cohort was established to investigate pesticide exposures from different agricultural activities. Maternal urinary organophosphate metabolites were measured at 28 weeks of pregnancy (n=86), delivery (n=67) and 2 months postpartum (n=51). Method: Subjects were interviewed with questionnaires about work, home and behavioral factors potentially associated with pesticide exposures, and spot urine samples were also collected. The urine samples were analyzed for dimethyl phosphate (DMP), diethyl phosphate (DEP), diethyl thiophosphate (DETP) and diethyl dithiophosphate (DEDTP), using gas chromatography-mass spectrometry. Results: The urinary DMP and dialkyl phosphate (DAP) concentrations at 28 weeks of pregnancy and delivery were not significantly different, but the DMP and DAP concentrations at 28 weeks of pregnancy and DAP concentrations at delivery were significantly different (p<0.05) from those at 2 months postpartum. The factors influencing the urinary DAP concentrations at 28 weeks of pregnancy included insecticide used in the home, living close to agricultural farmland, frequency of agricultural field visits during the first and second trimesters of pregnancies, occupation of subjects, pesticide used and other agricultural activities. Conclusions: The urinary organophosphate metabolites, DMP, DEP, DETP, DEDTP, total DEP and DAPs, at 28 weeks of pregnancy, delivery and 2 months postpartum fluctuated depending on their pesticide exposures both at home and in agricultural fields.(J Occup Health 2013; 55: 367-375)
収録刊行物
-
- journal of Occupational Health
-
journal of Occupational Health 55 (5), 367-375, 2013
公益社団法人 日本産業衛生学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204455266944
-
- NII論文ID
- 10031192210
-
- NII書誌ID
- AA11090645
-
- ISSN
- 13489585
- 13419145
-
- NDL書誌ID
- 024915023
-
- PubMed
- 23892639
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可