Impact of Adiponectin and Leptin on Long-Term Adverse Events in Japanese Patients With Acute Myocardial Infarction
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- Morita Yasuhiro
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Maeda Kengo
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Kondo Takahisa
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Ishii Hideki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Matsudaira Kyoko
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Okumura Naoki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Mitsuhashi Hirotsugu
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Shibata Rei
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
書誌事項
- タイトル別名
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- – Results From the Nagoya Acute Myocardial Infarction Study (NAMIS) –
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Background: Low adiponectin levels and high leptin levels are associated with a high incidence of developing cardiovascular disease. However, the relationship between the levels of these adipokines and the development of adverse events after acute myocardial infarction (AMI) remains unclear. Methods and Results: This study enrolled 724 Japanese subjects with AMI who underwent successful emergency percutaneous coronary intervention (PCI). Their serum adiponectin and leptin levels were measured 7 days after AMI onset. There were 63 adverse events during the 3-year follow-up. The levels of adiponectin and leptin and the leptin to adiponectin ratio, were significantly associated with adverse events [hazard ratio 2.08 (95% confidence interval (CI) 1.33–3.24), P=0.001; hazard ratio 0.62 (95% CI 0.43–0.90), P=0.012; hazard ratio 0.59 (95% CI 0.45–0.76), P<0.001, respectively]. The leptin to adiponectin ratio remained a significant independent predictor of adverse events during long-term follow-up in a multivariable analysis [adjusted hazard ratio 0.60 (95% CI 0.43–0.83), P=0.002]. Conclusions: Higher adiponectin and lower leptin levels are associated with a high incidence of adverse events in Japanese patients after AMI, and the leptin to adiponectin ratio independently predicts prognosis after AMI. (Circ J 2013; 77: 2778–2785)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 77 (11), 2778-2785, 2013
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205102079360
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- NII論文ID
- 10031196831
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- NII書誌ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BC3sXhvVamtLzO
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- ISSN
- 13474820
- 13469843
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- PubMed
- 23924849
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可