Site-selective Scission of Double-stranded DNA by Combining a Triplex-forming bis-PNA and Ce(IV)/EDTA

• Yuichiro Aiba

  Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba

• Kohei Yasuda

  Research Center for Advanced Science and Technology, The University of Tokyo

• Makoto Komiyama

  Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba

抄録

By combining triplex-forming bis-peptide nucleic acid (bis-PNA) with Ce(IV)/EDTA, double-stranded DNA was selectively hydrolyzed at a predetermined homopyrimidine/homopurine site, which is difficult to be targeted by the previous strategy using pseudocomplementary PNAs (pcPNAs). These homopyrimidine/homopurine sequences take various important roles in vivo, and thus, the present site-selective DNA cutters should be useful in biology, biotechnology, medicine, and other fields.

収録刊行物

• Chemistry Letters

  Chemistry Letters 42 (10), 1300-1302, 2013-10

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360565169058855040
• NII論文ID: 10031201345
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.130650
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/42/10/1300/55636252/cl.130650.pdf
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