<Originals>Mapping of the gracile axonal dystrophy (gad) gene (gad) using intraspecific backcrosses on mouse chromosome 5

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The gracile axonal dystrophy (gad) mouse which shows hereditary sensory ataxia and motor paresis has been morphologically characterized by the dying back type neuroaxonal dystrophy of the gracile fasciculus in the spinal cord, the swelling of the degenerated axon, and the formation of the spherical spheroid. The gad mouse serves as a useful animal model for the study of dying back neuroaxonal degeneration and the aging process. In the present study, two large back cross panels (Cross 1 : [(gad×C57BL/6J)F1×gad] and Cross 2 : [(gad×DBA/2J)F1×gad]) were established to obtain high resolution genetic mapping of the gad gene locus. The genetic orders of microsatellite DNA markers used were as follow, Cross 1 : centromere-D5Mit 81-D5Mit 233-D5Mit 184-D5Mit 254-D5Mit 256-D5Mit 197-gad-D5Mit 113-D5Mit 7,Cross 2 : centromere-D5Mit 290/302/303-gad. These data suggest that D5Mit 197,which is the nearest microsatellite marker from the gad gene, is a useful anchor for isolating the gad gene by chromosomal walking.

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