<Original Paper>Effects of diazepam and fluvoxamine on SART-stressed rats in the elevated plus-maze test : investigation of intracerebral serotonin action in anxiety

  • Kirime Eiji
    Department of Neuropsychiatry, Kinki University School of Medicine

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Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) confirmed to have a clinical anti-anxiety action. I investigated the anti-anxiety effect of fluvoxamine on SART-stressed rats from a behavioral pharmacology perspective using an elevated plus-maze and compared it with a benzodiazepine anti-anxiety agent, diazepam. In addition, the blood serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA), and melatonin concentrations and urinary 5-HIAA and melatonin concentrations were measured, and I investigated the results with reference to the behavioral pharmacology. Male Wistar rats aged six weeks were exposed to SART stress for five days during administration of fluvoxamine or diazepam, and anxiety was evaluated using an elevated plus-maze test. Fluvoxamine exhibited a similar or higher anti-anxiety effect than diazepam with regard to the frequency of entering arms of the elevated plus-maze and the time spent in arms, supporting the clinical anti-anxiety effect of fluvoxamine. There were no differences in the blood 5-HT, 5-HIAA, or melatonin concentration, but different tendencies were observed in the urinary 5-HIAA and melatonin concentrations between animals treated with fluvoxamine and diazepam. Although the possibility of interference by the circulatory system cannot be excluded, the differences may have reflected changes in 5-HT neurotransmitters in the central nervous system, showing that the two drugs have different pharmacological action mechanisms. SART-stressed animals may be useful as animal models for evaluation of anti-anxiety effects of SSRI including fluvoxamine.

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