Upregulation of CA 19-9 in the Mouse Kidney Following Unilateral Ureteral Obstruction
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High serum levels of carbohydrate antigen19-9 (CA19-9) have been detected in patients with pancreatic cancer and described in several recent case reports of patients with hydronephrosis. However, the mechanism of high serum levels of CA19-9 among hydronephrosis cases remains to be elucidated. In this study, we established a mouse unilateral ureteral obstruction (UUO) model to investigate the expression of CA19-9 protein in renal tissue. To investigate the progression of hydronephrosis following UUO, MR urography and pathological analysis were performed. CA19-9 expression was examined by immunohistochemistry and western blot analysis. MR urography revealed that the grade of pelvic dilatation increased in a time dependent manner. Pathologically, both interstitial cellular infiltration and fibrosis were detected from the second to the fourteenth day after surgery in UUO mice. CA19-9 was detected in the UUO kidney after the second day. The immunoblot analysis revealed that the elevated expression of CA19-9 was demonstrated at an early stage of obstructive nephropathy. Our study shows that the ureteral obstructed kidney is dominated by cell infiltration and induced fibrosis. The selective expression of CA19-9 was detected in renal fibrous tissue. Based on these findings, the level of CA19-9 might be a good indicator for onset of renal fibrosis induced by obstruction.
Acta medica Nagasakiensia. 2001, 46(1-2), p.21-25
収録刊行物
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- Acta medica Nagasakiensia
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Acta medica Nagasakiensia 46 (1-2), 21-25, 2001-06-20
長崎大学
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詳細情報 詳細情報について
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- CRID
- 1050005822262389248
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- NII論文ID
- 110000013906
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- NII書誌ID
- AA00508430
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- ISSN
- 00016055
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- HANDLE
- 10069/16176
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- 本文言語コード
- en
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- CiNii Articles