Pulmonary Hypertension in a Patient with Essential Thrombocythemia

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A 67-year-old woman with essential thrombocythemia (ET) developed acute heart failure and marked pulmonary hypertension (PH). No clear cause for the PH could be initially found. We suspected that thrombocytosis might cause PH. Treatments with anticoagulant (heparin and warfarin), platelet- lowering (hydroxyurea), and antiplatelet (ticlopidine) agents resulted in improvement of the clinical, hemodynamic conditions, and the control of platelet counts. We found that the main etiology of PH in the present case might be the pulmonary capillary obstruction from local pulmonary microthrombosis complicated with ET. Although PH associated with ET is uncommon, it should be always considered as a possible cause of dyspnea in patients with ET.

Acta medica Nagasakiensia. 2003, 48(1-2), p.61-65

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