Citrate Uptake by Isolated Rat Renal Brush Border Membrane Vesicles in Cadmium-Intoxicated Rats.
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- SATO Kazuhiro
- Department of Environmental Health, Fukui Medical School
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- KUSAKA Yukinori
- Department of Environmental Health, Fukui Medical School
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- ZHANG Qunwei
- Department of Environmental Health, Fukui Medical School
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- LI Benyi
- Department of Urology, Fukui Medical School
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- OKADA Kenichiro
- Department of Urology, Fukui Medical School
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- NAKAKUKI Kazuya
- Department of Pathology, Fukui Medical School
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- MURAOKA Ryusuke
- Department of Surgery, Fukui Medical School
書誌事項
- タイトル別名
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- Citrate Uptake by Isolated Rat Renal Br
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Epidemiological Studies have reported that the formation of renal stones is often observed in workers exposed to cadmium (Cd). Citrate is known to be a protective factor against renal stone formation. We previously reported that direct exposure to high-level cadmium impaired the citrate uptake by the brush border membrane vesicles (BBMV), which may mean that the formation of renal stones from exposure to Cd could be prevented. In the present study, to clarify the mechanism of Cd-induced renal stone formation, the characteristics of BBMV-induced citrate uptake were determined in Cd-intoxicated rats. Cd intoxication was induced by daily subcutaneous injections of CdCl2 at a dose of 2mg Cd/kg body wt per day for 17 to 20 days. The BBMV were prepared by the divalent cation precipitation method. Citrate uptake was measured by the Millipore rapid membrane filtration technique. The citrate uptake per mg protein was not significantly different between the two groups. The volume of BBMV was significantly reduced (50%) in Cd-intoxicated rats compared with that of control rats. Percentages of the equilibrium value were also significantly inhibited in Cd-intoxicated rats.
収録刊行物
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- Industrial health
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Industrial health 35 (3), 388-393, 1997
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390001204280257792
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- NII論文ID
- 130003550804
- 110000016715
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- NII書誌ID
- AA00672955
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- COI
- 1:CAS:528:DyaK2sXltlWltrc%3D
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- ISSN
- 18808026
- 00198366
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- NDL書誌ID
- 4405849
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- PubMed
- 9248223
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可