Effect of the Cholesterol Content on the Stability of Liposomes in the Blood Circulation

• 木下 洋夫

  Scool of Health Sciences, Kyushu University

• 澤原 英幸

  Faculty of Pharmaceutical Sciences, Kyushu University

• 後藤 茂

  Faculty of Pharmaceutical Sciences, Kyushu University

抄録

Liposomes composed of egg phosphatidylcholine (PC) and cholesterol (Chol), of which ratios (PC/Chol) were 1/1, 1/0.6, 1/0.2 were prepared, and the stabilities of these liposomes in the blood circulation were studied by the double fluorescent labeling method described in the previous report. As the result, it was proved that the liposome composed of 1/1 ratio of PC/Chol was stable enough, but with decreasing Chol contents of liposoomes, entrapped materials were leaked from liposomes. The result obtained in this study was in accordance with the previous reports and double fluorescent labeling method has been found very useful for the study on liposomes.

収録刊行物

• 九州大学医療技術短期大学部紀要

  九州大学医療技術短期大学部紀要 19 1-4, 1992-03

  Kyushu University School of Health Sciences Fukuoka, Japan

キーワード

• liposome
• phosphatidylcholine
• cholesterol
• stability
• double fluorescent labeling method
• carboxyfluorescein
• calcein

詳細情報

• CRID: 1390009224835753856
• NII論文ID: 110000055163
• NII書誌ID: AN00054674
• DOI: 10.15017/214
• HANDLE: 2324/214
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • CiNii Articles
• 抄録ライセンスフラグ: 使用可