<Originals>Muscular Changes of Diabetics with Special Reference to Findings of the Intramuscular Nerves

  • SATOU Takao
    Second Department of Pathology, Kinki University School of Medicine
  • MAEDA Mitsuyo
    Second Department of Pathology, Kinki University School of Medicine
  • HIRUMA Shingo
    Second Department of Pathology, Kinki University School of Medicine
  • KADOTA Eiji
    Second Department of Pathology, Kinki University School of Medicine
  • TAKAHASHI Manabu
    Second Department of Pathology, Kinki University School of Medicine
  • TAMURA Yoshisada
    Second Department of Pathology, Kinki University School of Medicine
  • MIZUHARA Yasuharu
    Second Department of Pathology, Kinki University School of Medicine
  • KITAO Tsutomu
    Second Department of Pathology, Kinki University School of Medicine
  • SAKATANI Kuniyasu
    Second Department of Pathology, Kinki University School of Medicine
  • HASHIMOTO Shigeo
    Second Department of Pathology, Kinki University School of Medicine
  • SENBA Emiko
    Department of Neuro-Anatomy, Institute of Higher Nervous Activity, Osaka University Medical School
  • NAMIKAWA Kiyohiro
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kinki University

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Other Title
  • <原著>糖尿病生検筋の所見 : 特に筋肉内の神経について

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Abstract

Since we noticed that the biopsied skeletal muscle revealed significant "neurogenic changes" in all of the given 13 cases of diabetics, electron microscopically we have studied thoroughly the changes of intramuscular nerve which might contain motor nerve axons. As far as the studies of peripheral nerves in the reports of diabetics the investigators are mostly referred to the sural nerve. We summarize the results as follows. (a) Changes of the motor end plates. 1. Degenerative changes with appearance of the myelin bodies in the nerve terminals. 2. Existence of "empty folds of synaptic clefts". (b) Changes of intramuscular nerve bundle. 1. Existence of perineurium in which the axon has reduced and/or disappeared. We (tentatively) call them "empty perineurium". 2. Degeneration of the remaining axons. 3. We have confirmed the morphologic changes in the intramuscular nerve which endorse the neurogenic changes of the muscle fibers.

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