Lifestyle-Related Risk Factors for Peptic Ulcer Disease : A Hospital-Based Case-Control Study in Akita Prefecture

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A case~control study was carried out to determine lifestyle~relatedrisk factors for peptic ulcer disease (PUD). The subjects, who resided in Akita, Japan, were 161 patients with PUD and 322 control subjects without PUD who underwent medical checkups, matched with patients by gender and age. All of the subjects underwent endoscopy and provided information on psychosocial factors and lifestyle practices through self~administered questionnaires. Blood samples were collected for determination of Helicobacter pylori (H. pylori) status. Lifestyle~relatedvariables were assessed for their associations with PUD and H. pylori infection by using multiple logistic regression analysis. The prevalences of H. pylori infection were 97.5% in the patients and 84.8% in the controls, which were higher than those in Japanese adults (i.e., from 23% to 73%). Significant risk factors for PUD were positive H. pylori status (odds ratio (OR) = 14.1), leanness (OR= 2.68), urban residency (OR= 2.57), irregular meal times (OR= 2.17), smoking habit (OR= 1.98), shift work (OR = 2.15), non~professional occupation (OR=2.64), lack of morale in job (OR= 2.13), and difficulty in mood change (OR=2.20). Significant risk factors for H. pylori infection were age of 40 years or over (OR=4.28) and rural origin (OR=3.l7). These findings suggest that smoking, leanness, and psychosocial stress in daily life are associated with PUD in the northeastern region of Japan where the prevalence of H. pylori infection is considerably high.

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  • 秋田医学

    秋田医学 31 (3-4), 211-220, 2004-12-01

    秋田医学会

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