The Distributions of Tau Short and Long Isoforms Fused with EGFP in Cultured Cells

• Kosaka, Satoru

• Takuma, Hiroshi

• Tomiyama, Takami

• Mori, Hiroshi

抄録

Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) are caused by mutations of the TAU gene. Many such mutations are located near the splicing site of exon 10 and affect the splicing ratio of 3-repeat/4-repeat tau isoforms (referred to as 3R-tau and 4R-tau) which contain 3 and 4 microtubule-binding domains, respectively. Little is known, however, concerning cellular localization of 3R-tau and 4R-tau. We examined the subcellular localization of tau isoforms in IMR-32 cells under differentiated conditions using the fusion proteins of tau isoforms probed with fluorescent protein (EGFP)...

収録刊行物

• Osaka City Medical Journal

  Osaka City Medical Journal 50 (1), 19-27, 2004-06

  OSAKA CITY MEDICAL CENTER

キーワード

• Tau isoform
• IMR-32
• Subcellular distribution
• EGFP-fused protein

詳細情報

• CRID: 1050001202450098944
• NII論文ID: 110001067219
• NII書誌ID: AA00765896
• ISSN: 00306096
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00306096-50-1-19
• Web Site: https://search.jamas.or.jp/link/ui/2006192764
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles