実験的な歯間離開がマウスの記憶能力と脳内神経伝達物質に及ぼす影響

• 神 智昭

  岩手医科大学歯学部歯科矯正学講座

書誌事項

タイトル別名

• The effects of experimental tooth separation on memory function and brain neurotransmitters in mice

抄録

In the present study, the effects of experimental separation of the lower incisor on memory function and the levels of brain neurotransmitters and related compounds were examined in mice at day 2, 7 and 14 after separation (0.5 or 1.0mm) treatment. The effects of the treatment on memory functions were tested by the multiple maze, T-maze and radial maze methods. The effects of the treatment on levels of neurotransmitter-related compounds in the hippocampus, cerebral cortex, striatum and hypothalamus were examined by high-performance liquid chromatography with an electrochemical detection system after the end of the each memory test. In mice, the experimental incisor separation induced dysfunction of all memory tested and increased the levels of 3-methoxy-1-hydroxyphenylglycol (MHPG), the main metabolite of the neurotransmitter noradrenaline, in all brain areas only on day 2 after treatment. These results suggest that incisor separation may inhibit the memory function of mice via activation of the central noradrenergic system.

収録刊行物

• 岩手医科大学歯学雑誌

  岩手医科大学歯学雑誌 28 (1), 38-53, 2003

  岩手医科大学歯学会

キーワード

• mouse
• tooth separation
• memory function
• brain neurotransmitters

詳細情報

• CRID: 1390282679567854720
• NII論文ID: 110001099949
• NII書誌ID: AN00017474
• DOI: 10.20663/iwateshigakukaishi.28.1_38
• ISSN: 24241822
• ISSN: 03851311
• Web Site: http://id.nii.ac.jp/1181/00001679/
• Web Site: https://search.jamas.or.jp/link/ui/2003253040
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • IRDB
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可