カイコにおよぼす5-ブロモウラシルおよび5-ブロモデオキシウリジンの影響I : とくに第1令の発育時期による差異

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タイトル別名
  • Effects of 5-Bromodeoxyuridine on the Silkworm, with Special Reference to Stage Differences during the First Instar
  • カイコにおよぼす5-ブロモウラシルおよび5-ブロモデオキシウリジンの影響
  • カイコ ニ オヨボス 5-ブロモウラシル オヨビ 5-ブロモデオキシウリジン ノ エイキョウ 1 トクニ ダイ1レイ ノ ハツイク ジキ ニ ヨル サイ
  • I. とくに第1令の発育時期による差異

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The effects of 5-bromodeoxyuridine (BUdR) and 5-bromouracil (BU) on growth, viability and induction of aberrant spots in the silkworm, Bombyx mori, were compared at different stages during the first instar. The strongest effect was observed when administered on the second day, at the middle of the instar, showing the lowest viability and highest mutability. At the last instar, the mean size of the spots induced by feeding on the first day was about twice as large as those treated on the third day. By estimating the bromine contents 14 hours after treatment, it was proved that the rate of BUdR or BU uptake on the second or third day was higher than that on the first day, and that the rate of BUdR uptake was several times higher than that of BU uptake in each period. This could be one of the reasons why treatment on the second day was more effective than that of the first day on inducing aberrant spots and larval death. The synergistic effect of γ-rays and BUdR on the production of aberrant spots was noticed when larvae were irradiated with γ-rays (800R) prior to the BUdR treatment on the first or third day, and also when larvae were irradiated after the BUdR treatment on the second day. It was suggested that these damages were due to the fact that the base analogues did form an integral part of the DNA structure, for the second day fell on the DNA synthetic period of the various tissues, more especially the epidermis, and as it had been said, more BUdR is incorporated into DNA, during its synthetic period or after γ-irradiation in microorganisms and culture cells.

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