血しょうアポリポタンパク質による脂質粒子認識のメカニズム

• 斎藤 博幸

  国立医薬品食品衛生研究所

• 半田 哲郎

  京都大学大学院薬学研究科

書誌事項

タイトル別名

• Recognition of Lipid Particle by Plasma Apolipoproteins.
• 血漿アポリポタンパク質による脂質粒子認識のメカニズム
• ケッショウ アポリポタンパクシツ ニ ヨル シシツ リュウシ ニンシキ ノ メカニズム

抄録

Binding of plasma apolipoproteins to surface membrane of lipid particles causes the strong positive curvature stain. Although apolipoproteins can hardly bind to egg phosphatidylcholine planar surface in bilayers, many apolipoproteins bind to the emulsion surface with significantly higher capacity compared to bilayers. This marked difference in apolipoprotein binding between bilayers and emulsions can be explained by the difference in mechanisms by which the apolipoprotein-induced membrane curvature stress is relaxed. The binding capacity of apolipoprotein A-I increases with increasing spontaneous negative curvature in bilayers, whereas in emulsions, the contribution of core lipids to the relief of curvature stress appears to be the key event for apolipoprotein binding.

収録刊行物

• 生物物理

  生物物理 39 (5), 285-289, 1999

  一般社団法人 日本生物物理学会

キーワード

• emulsions
• bilayers
• lipoproteins
• apolipoproteins
• membrane curvature

詳細情報

• CRID: 1390001206531647616
• NII論文ID: 110001153837
• NII書誌ID: AN00129693
• DOI: 10.2142/biophys.39.285
• COI: 1:CAS:528:DyaK1MXmsV2gsbc%3D
• ISSN: 13474219
• ISSN: 05824052
• NDL書誌ID: 4866113
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4866113
• Web Site: http://www.jstage.jst.go.jp/article/biophys/39/5/39_5_285/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000117643
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可