リボヌクレアーゼＨの多様性と分子機能

• 金谷 茂則

  大阪大学大学院工学研究科

書誌事項

タイトル別名

• Molecular Diversities and Functions of Ribonucleases H
• リボヌクレアーゼ H ノ タヨウセイ ト ブンシ キノウ

抄録

Ribonuclease H specifically cleaves the RNA strand of RNA/DNA hybrids. Based on the difference in the amino acid sequences, RNases H are classified into two major families, Type 1 and Type 2 RNases H. Type 1 and Type 2 RNases H share a common three-dimensional structure despite their poor amino acid sequence similarity. Whether their in vivo functions are cooperative or independent is of great interest. In addition, the enzymes, especially E. coli RNase HI, have been shown to be an excellent model not only for analyzing protein stability and protein folding, but also for protein engineering. I would like to summarize a recent progress in the RNase H studies.

収録刊行物

• 生物物理

  生物物理 43 (2), 75-80, 2003

  一般社団法人 日本生物物理学会

キーワード

• ribonuclease H
• classification
• catalytic mechanism
• stability
• protein engineering

詳細情報

• CRID: 1390282681507764224
• NII論文ID: 110001157610
• NII書誌ID: AN00129693
• DOI: 10.2142/biophys.43.75
• COI: 1:CAS:528:DC%2BD3sXivFOrsro%3D
• ISSN: 13474219
• ISSN: 05824052
• NDL書誌ID: 6526428
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6526428
• Web Site: http://www.jstage.jst.go.jp/article/biophys/43/2/43_2_75/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003193054
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可