塩酸グアニジンの吸湿特性に及ぼす添加剤と包装材料の影響

• 寺岡 麗子

  神戸薬科大学製剤学研究室

• 松田 芳久

  神戸薬科大学製剤学研究室

• 杉本 功

  (財) 田附興風会 北野病院薬剤部

書誌事項

タイトル別名

• Effects of Diluents and Packing Materials on the Hygroscopic Properties of Guanidine Hydrochloride.

抄録

Guanidine hydrochloride, which is known to be effective in the treatment of Lambert-Eaton myasthenic syndrome, is very hygroscopic. Therefore, the mixture of the drug and lactose dispensed at hospital pharmacies tends to easily liquefy even under ordinary storage conditions because of poor compatibility. In this study the physicochemical and chemical stabilities of commercially available guanidine salts, namely hydrochloride, nitrate, carbonate, and sulfate, were investigated at various relative humidity levels. The critical relative humidity of the hydrochloride salt was significantly lower than the others and it was also more hygroscopic than the other three salts, however, nitrate was found to be sufficiently stable regarding humidity. The powder maintained a good flowability after long storage periods. The optimal diluent was selected to use in powders consisting of guanidine hydrochloride in order to stabilize the physicochemical and chemical properties. No solidification or change in appearance were observed in the mixture of the drug and magnesium aluminometasilicate (Neusilin^® US₂) as diluent and moisture adsorbent. The flow property (angle of repose) of this mixture was also investigated.

収録刊行物

• 医療薬学

  医療薬学 28 (6), 521-529, 2002

  一般社団法人日本医療薬学会

キーワード

• guanidine hydrochloride
• hygroscopic properties
• angle of repose
• magnesium aluminometasilicate
• diluent
• packing material

詳細情報

• CRID: 1390282679753709312
• NII論文ID: 110001166640
• NII書誌ID: AA11527197
• DOI: 10.5649/jjphcs.28.521
• ISSN: 18821499
• ISSN: 1346342X
• Web Site: http://dl.ndl.go.jp/info:ndljp/pid/10557886
• Web Site: https://search.jamas.or.jp/link/ui/2003144750
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • NDL-Digital
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可