ゲフィチニブにより皮膚病変を来たした一例
書誌事項
- タイトル別名
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- Cutaneous Adverse Reactions in a Patient Treated with Gefitinib (Iressa)
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We report on the cutaneous adverse reactions of gefitinib (Iressa), an orally active, selective epidermal growth factor (EGF) receptor tyrosine kinase inhibitor that blocks signal transduction pathways, in a 19-year-old woman with recurrentmalignant glioma. When treated daily with 250mg gefitinib (p.o), the patient developed severe itching (Grade 2) and seborrheia (Grade 2) in the scalp, and acneiformeruption on the face (Grade 1) and upper limbs (Grade 1). The application offluocinonide lotion to her scalp did not improve the symptoms, but the antihistaminic ebastine was effective. These cutaneous adverse reactions result from of gefitinib's direct interference with EGF receptor signaling in the skin and further studiesshould be conducted to elucidate the mechanisms by which they occur.
収録刊行物
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- 医療薬学
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医療薬学 30 (5), 330-334, 2004
一般社団法人日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679751664384
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- NII論文ID
- 110001166810
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- NII書誌ID
- AA11527197
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- ISSN
- 18821499
- 1346342X
- http://id.crossref.org/issn/1346342X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可