Increased Activity of 2',5'-Oligoadenylate Synthetase in Peripheral Blood Mononuclear Cells of Patients with Major Depressive Disorder

• Yamada, Takeshi

• Ikuta, Kazufumi

• Kawahara, Ryuzo

• Sairenji, Takeshi

抄録

The aim of this study was to measure the activity of 2',5'-oligoadenylate synthetase (2',5'AS) which is mainly induced by interferon (IFN)-α and -β in patients with major depression and evaluate its relationship to the disease. 2',5'AS activity of 23 patients (male = 11, female = 12) with major depression and of 29 normal control subjects (male = 15, female = 14) was measured in peripheral blood mononuclear cells (PBMCs) by radioassay. The mean 2',5'AS activity in the PBMCs of the patients and that of the control subjects were 1.10 ± 0.69% and 0.72 ± 0.51%, respectively. The activity in the patients was statistically higher than that of the control subjects (P = 0.03). These results imply some abnormality in the IFN-2',5'AS system of patients with major depression.

収録刊行物

• Yonago Acta medica

  Yonago Acta medica 47 (1), 1-5, 2004-03

  Tottori University Faculty of Medicine

詳細情報

• CRID: 1050015354550510336
• NII論文ID: 110001218463
• NII書誌ID: AA00892882
• ISSN: 13468049
• Web Site: https://repository.lib.tottori-u.ac.jp/records/5087
• Web Site: https://search.jamas.or.jp/link/ui/2005200905
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles