肝病変におけるＣＤ３４（ｅｎｄｏｔｈｅｌｉａｌ　ｃｅｌｌ　ｍａｒｋｅｒ）の局在に関する免疫細胞化学的検討　　とくに肝細胞癌との鑑別について

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  • Immunocytochemical localization of CD34(endothelial cell marker) in liver disease: Focus on differential diagnosis of hepatocellular carcinoma.
  • focus on differential diagnosis of hepatocellular carcinoma
  • とくに肝細胞癌との鑑別について

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Objective: We evaluated the usefulness of the CD 34 antibody in cytological diagnosis of hepatocellular carcinoma (HCC) and benign hepatocytic lesions.<BR>Study design: We studied 38 scrape cytological specimens of liver disease, consisting of chronic hepatitis (4), liver cirrhosis (5), focal nodular hyperplasia (2), HCC (6 well diff., 7 moderately diff., 10 poorly diff., 4 undiff.). Specimens were examined uing ABC immunocytochemistry.<BR>Results: All HCC cases were positive for the CD 34 antibody in sinusoidal endothelial cells of tumor nests (100%: 27/27). Fine sinusoidal capillary vessels were positive for CD 34 in well diff. HCC, while thick or and peripheral vessels were positive in moderately diff., poorly diff. and undiff.<BR>Conclusion: We believe that the CD 34 antibody is useful in differential diagnosis of HCC from other liver diseases and the degree of HCC differentiation.

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