Reactive mesothelia, pulmonary adenocarcinoma, and malignant mesothelioma with pleural effusion, with special reference to the nucleus number.

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  • 核数に注目した反応性中皮，肺腺癌および悪性中皮腫の特徴

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Abstract

Objective: We assessed the diagnostic value of counting nucleus numbers for differentiating cells among lung adenocarcinoma (LC), malignant mesothelioma (MM), and reactive mesothelia (RM) with pleural effusion.<BR>Study Design: Samples were obtained by thoracocentesis of 43 cases with pleural effusion (30 malignancies (14 LC and 16MM) and 13 benign (RM)). The following parameters were evaluated for each specimen:(1) percentages of cells with 1, 2, 3, and 4 or more nuclei among 300 consecutive cells (PN=1, PN=2, PN=3, PN≥4), (2) maximum nuclear count per cell for all cells (Nmax).<BR>Results: (1) PN=1 of RM (90.0±2.0%) and LC (86.4±8.3%) was significantly higher than that of MM (77.2±7.3%).PN=2 of RM (8.7±1.6), and LC (12.5±7.2) was significantly lower than that of MM (20.1±7.0). PN = 3 of 2.0% or more was found only in malignant specimens (2 LC and 6 MM).(2) Nmax of MM was significantly higher than those of RM and LC, and Nmax of 10 or more was found in only 8 MM.<BR>Conclusion: Counting the nucleus number may be helpful in differentiating these three diseases.

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