GENE DELIVERY INTO THE CHICKEN EMBRYO BY USING REPLICATION-COMPETENT RETROVIRAL VECTORS

• SATO NOBORU

  )Department of Anatomy, Fukushima Medical University School of Medicine

抄録

Rous sarcoma virus (RSV)-derived retroviral vectors have allowed for efficient gene transfer into the chicken embryo which is a classical model for studying vertebrate development. Current evidence reveals that this method can be used for regionally restricted expression, inducible expression, and for interfering with endogenous gene function, suggesting that gain-of-function and loss-of-function strategies for specific genes can be achieved spatially and temporally in the avian embryo. Thus, retroviral-mediated gene transfer into the chicken embryo coupled with a wide variety of strategies is now an important tool to address specific biological questions in the vertebrate.

収録刊行物

• 福島医学会

  福島医学会 50 (2), 37-46, 2004

  福島医学会

キーワード

• replication-competent retroviral vector
• chicken embryo
• promoter
• inducible gene expression
• doxycycline

詳細情報

• CRID: 1390282681283350656
• NII論文ID: 110001234301
• NII書誌ID: AA0065246X
• DOI: 10.5387/fms.50.37
• COI: 1:CAS:528:DC%2BD2MXisVOlu70%3D
• ISSN: 21854610
• ISSN: 00162590
• PubMed: 15779569
• Web Site: http://ir.fmu.ac.jp/dspace/handle/123456789/156
• Web Site: https://search.jamas.or.jp/link/ui/2006125743
• 本文言語コード: en
• データソース種別:
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  • IRDB
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• 抄録ライセンスフラグ: 使用不可