TWO-STAGE TESTING TO ESTABLISH NON-INFERIORITY IN THE STRATIFIED 2×2 CONTINGENCY TABLES

• KOSHIMIZU Takashi

  Graduate School of Engineering, Osaka Electro-Communication University

• TSUJITANI Masaaki

  Department of Engineering Informatics, Osaka Electro-Communication University

Abstract

In this article we propose a two-stage testing procedure for demonstrating noninferiority of a test drug in stratified 2×2 contingency tables, which includes a preliminary test of homogeneity of odds ratios. In order to prove that a new drug is not inferior to a control by more than a prescribed amount, we use model-based methods such as the weighted least-square (WLS) procedure by Grizzle et al. (1969), and test the null hypothesis of a specified non-unity ratio. Also included are some results of a Monte Carlo study conducted to investigate the accuracy of the proposed test to the null distribution, and power of the test under small and moderate sample size configurations.

Journal

• Journal of the Japanese Society of Computational Statistics

  Journal of the Japanese Society of Computational Statistics 11 (1), 25-39, 1998-12-01

  Japanese Society of Computational Statistics

Keywords

• Homogeneity test
• Stratified 2×2 contingency tables
• Power
• Monte Calro simulation

Details

• CRID: 1572824501768024448
• NII Article ID: 110001235563
• NII Book ID: AA10823693
• ISSN: 09152350
• Text Lang: en
• Data Source:
  • CiNii Articles