乳腺腫瘍に対する酵素組織化学的反応, 特に加水分解酵素系 (Alkaline phosphatase, Acid phosphatase, β-Glucuronidase) の細胞診への応用について

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  • Study on Application of Enzyme Histochemical Staining, Especially Hydrolylase (Alkaline phosphatase, Acid phosphatase, β-Glucuronidase) to Cytological Diagnosis in Mammary Tumor

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Mammary tumors were studies, aiming at elucidation of the borderline of benign and malignant findings from the standpoint of cytological diagnosis, using 3 kings of hydrolases, i. e. Alkaline phosphatase, Acid phosphatase, and β-Glucuronidase, concomitantly with the general Papanicolaou method. The materials were the aspiration smear from the tumor lesion, abrasion cytology, and inprint specimens from the postoperated and biopsied mammary tumors.<BR>Examinations at tissue level were conducted in the first experimental group consisting of 15 patients with malignant tumors and 15 subjects without cancer, and also examinations were carried out, concomitantly using cytology and histology in the second experimental group consisting of 13 caneros patients, i. e. 12 cases with infiltration cancer and 1 case with non-infiltration cancer, and 13 non-cancerous patients.<BR>As a result Alkaline phosphatase reactions showed negative results of all cancerous lesions irrespective of the tissue pattern of malignant tumors, cytodiagnostically the majority of malignant atypical cells due to the Papanicolaou method showed the disappearance and marked decrease of the activity. In 1 case of non-infiltration cancer, cells with weak activity existed maixing. In non-cancerous cases obviously positive reactions were observed irrespective of mastopathy, fibroadenoma, etc.<BR>The reactions of Acid phosphatase, β-Glucuronidase, etc. hardly showed any difference in the activity of atypical cells between cancerous cases and non-cancerous cases, and histologically strong activity was observed in the epithelium of apoerine metaplasia, adenosis, etc.<BR>Thus, it has been concluded that concerning the diagnosis of benign and malignant atypical cells in mammary tumors, the concomitant use of the usual Papanicolaou method with Alkaline phosphatase reaction is one of the significant methods to elucidate the borderline lesion.

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