末梢血幹細胞移植（ＰＢＳＣＴ）併用大量化学療法後に切除し，腫ようマーカーが正常となった前縦隔はい細胞性腫ようの一例

• 伊藤 宏之

  神奈川県立がんセンター呼吸器外科

• 中山 治彦

  神奈川県立がんセンター呼吸器外科

• 荒井 宏雅

  神奈川県立がんセンター呼吸器外科

• 正津 晶子

  神奈川県立がんセンター呼吸器外科

書誌事項

タイトル別名

• A case of anterior mediastinal germ cell tumor successfully resected after high-dose chemotherapy in conjunction with peripheral blood stem cells.

抄録

A 29-year-old man had chest pain and was found to have an anterior mediastinal tumor. A needle biopsy using computed tomographic imaging revealed a germ cell tumor composed of embryonal carcinoma and teratoma. The serum concentration of alpha-fetoprotein (AFP) was elevated at 9600 ng/ml, but all other tumor markers including beta-human chorionic gonadotropin were in the normal ranges. On December 16, 2000, combined chemotherapy (PEB regimen: cisplatin+etoposide+bleomycin) was administered twice, and high-dose chemotherapy (ICE regimen: carboplatin+etoposide+ifosfamide) followed by peripheral blood stem cell transplantation was also performed twice. After chemotherapy, the serum concentration of AFP decreased to 44.3 ng/ml, but was still high. Surgical resection followed by chemotherapy (PE regimen: cisplatin+etoposide) was performed, and the serum concentration of AFP decreased to a normal level 28 days after surgery. Histological examination of resected specimen revealed an immature teratoma. At present six months after surgery, the serum concentration of AFP is at a normal level and there are no signs of recurrence.

収録刊行物

• 日本呼吸器外科学会雑誌

  日本呼吸器外科学会雑誌 16 (4), 548-553, 2002

  特定非営利活動法人 日本呼吸器外科学会

キーワード

• 前縦隔腫瘍
• 性腺外胚細胞性腫瘍
• 末梢血幹細胞移植
• 大量化学療法
• α-胎児性蛋白

詳細情報

• CRID: 1390282679337838720
• NII論文ID: 110001269991
• NII書誌ID: AN10467885
• DOI: 10.2995/jacsurg.16.4_548
• ISSN: 18814158
• ISSN: 09190945
• Web Site: https://search.jamas.or.jp/link/ui/2002222348
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可