肺切除における術直前ステロイド投与の功罪―術後間質性肺炎予防に向けて―

• 矢野 篤次郎

  佐賀県立病院好生館呼吸器外科

• 古賀 聡

  中津市立中津市民病院呼吸器外科

書誌事項

タイトル別名

• Prophylactic administration of methylprednisolone for interstitial pneumonia after pulmonary resection.
• 術後問質性肺炎予防に向けて

抄録

(Objectives) The aim of the present study was to investigate both the benefits and adverse effects of prophylactic administration of methylprednisolone for interstitial pneumonia (IP) after pulmonary resection.<BR>(Methods) We reviewed 41 patients with primary lung cancer who underwent complete resection. Of these, 24 patients who had two or more risk factors for postoperative IP were given 125mg of methylprednisolone intravenously just before the thoracotomy. The risk factors included male gender, Brinkmann index >600, and the presence of interstitial changes on chest CT.<BR>(Results) The serum CRP on the third postoperative day (POD) was significantly lower in the steroid group than in control (8.5±5.2mg/dlvs. 13.3±4.2mg/dl, p=0.011) while it was not different between those two groups on the seventh POD (1.9±1.3 vs. 2.0±2.0, p=0.942). Both the mean days of postoperative hospital stay and the disease-free survival were not different between the two groups.<BR>(Conclusion) Prophylactic administration of methylprednisolone suppressed the inflammatory response during the early postoperative days, and no adverse effect on wound healing or disease-progression was identified.

収録刊行物

• 日本呼吸器外科学会雑誌

  日本呼吸器外科学会雑誌 17 (6), 640-643, 2003

  特定非営利活動法人 日本呼吸器外科学会

キーワード

• 肺切除
• 周術期管理
• 肺癌
• ステロイド
• 間質性肺炎

詳細情報

• CRID: 1390282679337722112
• NII論文ID: 110001270082
• NII書誌ID: AN10467885
• DOI: 10.2995/jacsurg.17.640
• ISSN: 18814158
• ISSN: 09190945
• Web Site: https://search.jamas.or.jp/link/ui/2004069282
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可