呼吸器外科手術における予防的抗菌薬投与の意義

DOI 機関リポジトリ HANDLE 被引用文献3件 参考文献8件

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  • Prophylactic antibiotic guidelines for respiratory surgery

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The prophylactic antibiotic guidelines for respiratory surgery were showed in 2001 as a special edition of the Journal of Japan Surgical Society. The guideline recommended second-generation cephalosporin or penicillin antibiotic agent administered for 3 to 4 days following surgery.<BR>We considered this dosage to be excessive for routine practice. We prospectively applied a guideline of administering cefazolin right before and three hours after respiratory surgery and reviewed the safety and validity. By April 2003, we had applied the guidelines in 237 consecutive patients. Of these, 166 patients were treated under our guidelines, while 71 patients received additional antibiotics based on the guidelines' exception rules: patients with excess sputum or body temperature over 38.5°C on the first postoperative day. There were no guideline-related adverse events.<BR>In conclusion, prophylactic cefazolin twice on the day of respiratory surgery was safe and valid.

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